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HORSE TIMES is a complimentary quarterly English-language magazine established in Egypt in 1997. It is the only English language publication in the Middle East dedicated to improving access .. read more..

Horse Times Magazine :: Summer Issue # 54

PUBLISHED SUMMER 2017, ISSUE 54 FEATURES:

THE ROLEX GRAND PRIX AT CHIO AACHEN
GREGORY WATHELET CLAIMS VICTORY

60 SECONDS WITH
IBRAHIM EL BASTAWISY

A HORSEMAN’S BLUEGRASS PARADISE
LEXINGTON, KENTUCKY

PRACTICAL TIPS
FEI DOPING CASESFEI DOPING CASES

“THE MOSTEST HOSS THERE EVER WAS..

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Horse Times Weekly Headlines :: Issue # 30

FEI SECRETARY GENERAL ELECTED PRESIDENT OF NEW PARALYMPIC ASSOCIATION

EDWINA TOPS-ALEXANDER BACK ON TRACK

USA ON TOP WITH KENT FARRINGTON TOPPING THE WORLD RANKING FOR A FIFTH CONSECUTIVE MONTH

FEI PRESIDENT INGMAR DE VOS ELECTED AS IOC MEMBER

SWEDISH CAPITAL JOINS WORLD’S PREMIER SHOWJ..

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HORSE TIMES RELEASES A NEW BOOK


ALLTECH FEI WORLD EQUESTRIAN GAMES
NORWAY 2014

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>> DRUG EFFECTS ON STEM CELLS
Date: Monday, August 1, 2016
Horse Times Egypt: Equestrian Magazine :News :DRUG EFFECTS ON STEM CELLS

Equine Veterinary Journal Early View June 2016

 

Heather Ferguson

 

Influence of commonly used pharmaceutical agents on equine bone marrow-derived mesenchymal stem cell viability
.

 

Edmonds, R.E., Garvican, E.R., Smith, R.K.W. and Dudhia, J.

 

 

Bone marrow derived stem cells (3 horses) and tendon derived somatic cells (2 horses) were resuspended in media containing various commonly used drugs at clinically relevant concentrations and cell viability and cell proliferation were assessed.

 

At the start of the study mean cell viability was 95%. Exposure to romifidine or mepivacaine did not significantly affect viability or proliferation. At the highest concentration of detomidine and butorphanol, stem cell viability was significantly reduced compared with controls. Although xylazine exposure caused a significant, dose-dependent reduction in stem cell viability compared with controls, overall population viability remained good. Mepivicaine, romifidine, butorphanol and detomidine had no effect on stem cell proliferation.

 

Both corticosteroid formulations tested (methylprednisolone and triamcinolone) significantly reduced viability at all doses. Methylprednisolone especially caused rapid stem cell death with no live cells observed after 1 hour in high dose suspension. Both corticosteroids caused a dose-dependent reduction in viability differentiated tendon derived cells.

 

 

Bottom line:

 

These are in vitro results but they do raise concern about the concurrent use of corticosteroids and stem cell therapy. The study also suggests corticosteroid administration into the sheath of a damaged tendon cannot be recommended.

 

 

--Ends--

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