HORSE TIMES Magazine :: THE LEADING EQUESTRIAN MAGAZINE IN THE MIDDLE EAST
Add HorseTimes Egypt's Equestrian Magazine to your Favorites Join HorseTimes Egypt's Equestrian Magazine on Facebook Subscribe to HorseTimes Egypt's Equestrian Magazine on Youtube Follow HorseTimes Egypt's Equestrian Magazine on Google+ Pin HorseTimes Egypt's Equestrian Magazine Photos Follow HorseTimes Egypt's Equestrian Magazine Latest News
HOME PROFILE ADVERTISE SUBSCRIBE LINKS CONTACT

The Leading Equestrian Magazine In The Middle East

Welcome To Horse Times
HORSE TIMES is a complimentary quarterly English-language magazine established in Egypt in 1997. It is the only English language publication in the Middle East dedicated to improving access .. read more..

Horse Times Magazine :: Spring Issue # 53

PUBLISHED SPRING 2017, ISSUE 53 FEATURES:

20TH ANNIVERSARY
HRH PRINCESS HAYA BINT AL HUSSEIN

20TH ANNIVERSARY
RIDERS’ PROFILES

20TH ANNIVERSARY
BLUE BLOOD ADDICTED TO HORSES

20TH ANNIVERSARY
BEHIND THE SCENES

20TH ANNIVERSARY
CELEBRITIES WITH PASSION FOR HORSES

20TH ANNIVERSAR..

VIEW MAGAZINE ISSUES HERE >>

Horse Times Weekly Headlines :: Issue # 29

LGCT CHANTILLY: JÉRÔME GUERY VICTORIOUS IN HOTLY CONTESTED CSI5*

TRYON SUMMER SERIES 2017: ANDREW RAMSAY & COCQ A DOODLE WIN FINAL GRAND PRIX

DUTCH DELIVER AT LAST IN FABULOUS FALSTERBO FEI NATIONS CUP™ JUMPING

WINS CSIO5* €200, 00 GRANDPRIX STEVE GUERDAT

LGCT CHANTILLY HARRIE AND EMERAL..

VIEW HEADLINES ISSUES HERE >>

HORSE TIMES RELEASES A NEW BOOK


ALLTECH FEI WORLD EQUESTRIAN GAMES
NORWAY 2014

Download here >>
NEWS EVENTS HEADLINES ISSUES ARTICLES VIDEOS STREAMING BLOG
HORSE TIMES NEWS DETAILS
>> NOVEL IMMUNOTHERAPY FOR SWEET ITCH
Date: Sunday, January 15, 2017
Horse Times Egypt: Equestrian Magazine :News :NOVEL IMMUNOTHERAPY FOR SWEET ITCH

Oral administration of transgenic barley expressing a Culicoides allergen induces specific antibody response


 

Jonsdottir, V. Svansson, S. B. Stefansdottir, E. Mäntylä, E. Marti and S. Torsteinsdottir

 

 

This in vivo study investigated a novel immunotherapy approach to Culicoides insect bite hypersensitivity (sweet itch). Barley grain expressing hyaluronidase protein originating from Culicoides saliva was fed to four Icelandic horses (immunologically naïve to Culicoides) while three controls were fed normal barley. Horses were treated six times over a period of 20 weeks with 50–100 g of barley grain each time, up to 400 g in total. Eight months after the last treatment, horses were all ‘boosted’ with 100 g.

 

Blood and saliva were collected from the horses before and 2 weeks after each treatment and tested with an ELISA for IgG antibodies to two Culicoides proteins. After the transgenic barley treatment, three of four horses showed an IgG1 response and all four horses were successfully boosted, significantly different from controls. A competitive inhibition ELISA showed that after the boost, transgenic barley-treated horses’ sera inhibited binding of IgE to one of the Culicoides proteins.  A further competitive inhibition ELISA showed that the two proteins are not fully cross-reactive. These results show that the transgenic barley is effective at inducing an allergen-specific response and that antibodies produced are able to partially inhibit IgE binding to allergens from Culicoides species.

 

 

Bottom line:

 

Oral treatment of horses with transgenic barley expressing Culicoides proteins results in an allergen-specific response and warrants further study as an immunotherapy treatment for insect bite hypersensitivity.

 

 

Photo: www.sweet-itch.org

 

 

--Ends--

COMMENTS




Upcoming Events & Coverages



Olympia Horse Show (13-19 December 2016) - EQUIST (19-21 May 2017)

Copyright 2009 - 2017 © Horse Times. All rights reserved. powered by zanss.com