HORSE TIMES Magazine :: THE LEADING EQUESTRIAN MAGAZINE IN THE MIDDLE EAST
Add HorseTimes Egypt's Equestrian Magazine to your Favorites Join HorseTimes Egypt's Equestrian Magazine on Facebook Subscribe to HorseTimes Egypt's Equestrian Magazine on Youtube Follow HorseTimes Egypt's Equestrian Magazine on Google+ Pin HorseTimes Egypt's Equestrian Magazine Photos Follow HorseTimes Egypt's Equestrian Magazine Latest News
HOME PROFILE ADVERTISE SUBSCRIBE LINKS CONTACT

The Leading Equestrian Magazine In The Middle East

Welcome To Horse Times
HORSE TIMES is a complimentary quarterly English-language magazine established in Egypt in 1997. It is the only English language publication in the Middle East dedicated to improving access .. read more..

Horse Times Magazine :: Spring Issue # 53

PUBLISHED SPRING 2017, ISSUE 53 FEATURES:

20TH ANNIVERSARY
HRH PRINCESS HAYA BINT AL HUSSEIN

20TH ANNIVERSARY
RIDERS’ PROFILES

20TH ANNIVERSARY
BLUE BLOOD ADDICTED TO HORSES

20TH ANNIVERSARY
BEHIND THE SCENES

20TH ANNIVERSARY
CELEBRITIES WITH PASSION FOR HORSES

20TH ANNIVERSAR..

VIEW MAGAZINE ISSUES HERE >>

Horse Times Weekly Headlines :: Issue # 28

• LGCT CANNES CSI5*: A SPECTACULAR WIN FOR LORENZO DE LUCA

• ATHINA ONASSIS HORSE SHOW CSI5* CHRISTIAN AHLMANN WINS THE LONGINES GP

• WARD AND ROTCHILD RECLAIM VICTORY IN SAPPHIRE GRAND PRIX DEVON CSI4*

• LGCT GRAND PRIX CANNES: MOYA WINS AND SMOLDERS HITS RANKING LEAD

• FEI NATIONS CUP..

VIEW HEADLINES ISSUES HERE >>

HORSE TIMES RELEASES A NEW BOOK


ALLTECH FEI WORLD EQUESTRIAN GAMES
NORWAY 2014

Download here >>
NEWS EVENTS HEADLINES ISSUES ARTICLES VIDEOS STREAMING BLOG
HORSE TIMES NEWS DETAILS
>> HYPERTHERMIA AND MACROLIDE ANTIMICROBIALS
Date: Wednesday, October 28, 2015
Horse Times Egypt: Equestrian Magazine :News :HYPERTHERMIA AND MACROLIDE ANTIMICROBIALS

Equine Veterinary Journal Early View September 2015

By Heather Ferguson

 

Macrolide-induced hyperthermia in foals: Role of impaired sweat responses

Stieler, A.L., Sanchez, L.C., Mallicote, M.F., Martabano, B.B., Burrow, J.A. and MacKay, R.J.

 

Hyperthermia is a potentially fatal side effect of erythromycin and foals kept outside in warm weather are at particular risk. This study aimed to investigate whether this adverse effect was caused by drug-induced anhydrosis (inhibition of sweating).

 

Ten pony foals aged 2-3 months received either erythromycin or a control (lactose solution) 3 times daily. For the first 10 days they were kept with their dams in covered shaded stalls and from Day 11 to Day 20 they were kept out at pasture with both shaded and non-shaded areas available. Rectal temperature was measured 3 times daily in stalls and twice daily while turned out. Respiratory rate, heart rate and faecal consistency were recorded and the foals were monitored closely for signs of heat stress.

 

To investigate the effects of erythromycin treatment on sweat production, intradermal terbutaline sweat tests were performed in both treated and control groups on Days 1, 3, 10 and 20. This involved intradermal injection of serial dilutions of terbutaline in saline at 6 sites on the neck and placement of an absorbent pad over the injection sites. After 30 minutes the pad was removed and the weight change measured to assess the amount of sweat produced.

 

Terbutaline-induced sweating was significantly lower in erythromycin treated foals at all time points in the study compared to Day 1 levels. At all time points except Day 20, sweat weight was significantly lower in the erythromycin treated group than in the control group. Sweating function partially recovered after 10 days of treatment; however, at Day 20 (10 days following the end of treatment), mean sweat weights were still lower than 50% baseline values, indicating sweating function seems to take longer than this to recover. Maximal rectal temperatures were higher in erythromycin-treated foals than those in the control group, and treated foals appeared more susceptible to higher environmental temperatures.

 

 

Bottom line:

 

Hyperthermia in erythromycin-treated foals is related to a drug-induced anhydrosis. This is most prominent in the first few days of treatment, after which sweating function partially recovers, but sweating remains inhibited for more than 10 days following the end of treatment.

 

 

--Ends--

COMMENTS




Upcoming Events & Coverages



Olympia Horse Show (13-19 December 2016) - EQUIST (19-21 May 2017)

Copyright 2009 - 2017 © Horse Times. All rights reserved. powered by zanss.com