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HORSE TIMES is a complimentary quarterly English-language magazine established in Egypt in 1997. It is the only English language publication in the Middle East dedicated to improving access .. read more..

Horse Times Magazine :: Spring Issue # 53

PUBLISHED SPRING 2017, ISSUE 53 FEATURES:

20TH ANNIVERSARY
HRH PRINCESS HAYA BINT AL HUSSEIN

20TH ANNIVERSARY
RIDERS’ PROFILES

20TH ANNIVERSARY
BLUE BLOOD ADDICTED TO HORSES

20TH ANNIVERSARY
BEHIND THE SCENES

20TH ANNIVERSARY
CELEBRITIES WITH PASSION FOR HORSES

20TH ANNIVERSAR..

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Horse Times Weekly Headlines :: Issue # 28

• LGCT CANNES CSI5*: A SPECTACULAR WIN FOR LORENZO DE LUCA

• ATHINA ONASSIS HORSE SHOW CSI5* CHRISTIAN AHLMANN WINS THE LONGINES GP

• WARD AND ROTCHILD RECLAIM VICTORY IN SAPPHIRE GRAND PRIX DEVON CSI4*

• LGCT GRAND PRIX CANNES: MOYA WINS AND SMOLDERS HITS RANKING LEAD

• FEI NATIONS CUP..

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HORSE TIMES RELEASES A NEW BOOK


ALLTECH FEI WORLD EQUESTRIAN GAMES
NORWAY 2014

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>> ANTI-INFLAMMATORIES IN EHV-1 INFECTION
Date: Sunday, February 19, 2017
Horse Times Egypt: Equestrian Magazine :News :ANTI-INFLAMMATORIES IN EHV-1 INFECTION

Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro

 

S. Goehring, K. Brandes, L. V. Ashton, L. A. Wittenburg, F. J. Olea-Popelka, D. P. Lunn and G. Soboll Hussey

 

 

This in vitro study set out to determine the effects of several anti-inflammatory drugs on endothelial cells infected with equine herpesvirus-1 (EHV-1). The drugs tested were acetylsalicylic acid, lidocaine hydrochloride 2%, firocoxib, flunixin meglumine and dexamethasone sodium disphosphate at therapeutic concentrations. Peripheral blood mononuclear cells (PBMC) were infected with EHV-1, and three experiments were performed.

 

Experiment 1 used immortalised equine carotid artery cells. The degree of infection and subsequent cell lysis was detectable as a ‘plaque’, allowing cell infection to be measured by ‘plaque count per well’. All five anti-inflammatory drugs resulted in significantly decreased plaque counts compared to non-treated monolayers. Experiment 2 used brain-derived endothelial cells and significant reduction in plaque counts were observed in monolayers treated with lidocaine, firocoxib and dexamethasone. Experiment 3 evaluated the effect of the drugs over a restricted 24-hour period on infected PBMC alone, brain endothelial cells alone or both together. Lidocaine and firocoxib significantly reduced plaque counts when both types of cells were incubated together. This effect was not seen when only one cell type was infected, with the exception of dexamethasone, which significantly decreased plaque counts in PBMC cells.

 

These results provide further evidence that infection of the central nervous system with EHV-1 appears to occur by contact between infected PBMC and endothelial cells. Crucially, infection of endothelial cells in vitro is reduced by incubation with anti-inflammatory drugs, including commonly used NSAIDs. More research is warranted to determine whether anti-inflammatories result in reduced infection rates in clinical cases of disease.

 

 

Bottom line:

 

Pro-active use of anti-inflammatories in the early stage of EHV-1 neurological disease may be beneficial, with more research needed in this area.

 

 

--Ends--

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